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. Author manuscript; available in PMC: 2020 May 15.
Published in final edited form as: Cancer Res. 2019 Mar 25;79(10):2649–2661. doi: 10.1158/0008-5472.CAN-18-2331

Figure 7. Selective targeting of melanoma cells with high endogenous MITF expression by the p300 histone acetyltransferase inhibitor, A-485*.

Figure 7.

(A) Panel of melanoma cell lines evaluated for MITF expression by immunoblot blot and qRT-PCR. (B) Relative growth of human melanoma cell lines following A-485* treatment. Cells were subjected to 6-days of treatment with A-485* (10 μM). (C) Box-plot analysis of cytotoxic effects of A-485* in two groups of melanoma cell lines expressing high and low levels of MITF. Error bars, SD; ***p<0.001. (D) MITF gene promoter luciferase assay in WM983B melanoma cells treated with A-485* and DMSO. Error bars, SD; *p<0.05. (E) Schematic model illustrating the p300-MITF-FOXM1 transcriptional axis regulating melanoma cell growth.