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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: J Neuroophthalmol. 2019 Jun;39(2):191–199. doi: 10.1097/WNO.0000000000000760

Figure 2. Continuous ST266 treatment preserves OKR for 8 weeks in EAE optic neuritis.

Figure 2.

OKR responses significantly (***p<0.001) decreased in the eyes of PBS- (N=12) or HSA-treated EAE mice (N=12) compared with control mice (N=8), starting from day 14 and progressing over time until sacrifice at day 56 post-immunization. EAE mice that received either once or twice daily doses of intranasal ST266 from days 15 to 30 (N=12), showed a delay in OKR decreases but no significant preservation of OKR by day 56. EAE mice that received either once (@p<0.05) or twice (@@p<0.01) daily doses of intranasal ST266 continuously from day 15 to 56 (N=12) showed a significant preservation of OKR compared with both PBS- and HSA-treated EAE mice.