Skip to main content
. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Adv Drug Deliv Rev. 2018 Nov 16;145:73–95. doi: 10.1016/j.addr.2018.11.004

Figure 12.

Figure 12.

Enhanced delivery of siRNA into skin tissues by a skin penetrating and cell entering (SPACE) peptide identified from phage biopanning. (A) The structure of SPACE functionalized siRNA-carrying liposomes. (B) Confocal microscopy images of the skin penetration profiles of SPACE (B-1) and control peptide (B-2) into porcine skin, respectively, showing that the SPACE peptide could efficiently penetrate across stratum corneum into epidermis and dermis layers. (C) Percentage knockdown of GAPDH protein levels in mice 72 h after treatment, showing that SPACE could deliver siRNA into the skin and reduce the GAPDH expression level. (Reprinted with permission from ref. [96], copyright 2014, Elsevier and ref. [92], copyright 2011, National Academy of Sciences)