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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Nat Neurosci. 2019 Feb 4;22(3):343–352. doi: 10.1038/s41593-018-0326-7

Figure 3.

Figure 3

Chord diagram of genes significantly associated (P < 2.80 × 10-6) with depression and the second level Anatomical Therapeutic Chemical classifications to which interacting drugs have been assigned. The width of each line is determined by the number of drugs known to interact with each gene. The genes are ordered by significance with depression with those most significantly associated located at the top of the diagram

The second level Anatomical Therapeutic Chemical classifications identified were: Stomatological preparations (A01), Drugs for acid related disorders (A02), Drugs for functional gastrointestinal disorders (A03), Bile and liver therapy (A05), Drugs for constipation (A06), Drugs used in diabetes (A10), Vitamins (A11), Mineral Supplements (A12), Anabolic agents for systemic use (A14), Blood substitutes and perfusion solutions (B05), Other hematological agents (B06), Cardiac therapy (C01), Diuretics (C03), Peripheral vasodilators (C04), Vasoprotectives (C05), Beta blocking agents (C07), Calcium channel blockers (C08), Corticosteroids, dermatological preparations (D07), Anti-acne preparations (D10), Other dermatological preparations (D11), Other gynecologicals (G02), Sex hormones and modulators of the genital system (G03), Urologicals (G04), Pituitary and hypothalamic hormones and analogues (H01), Corticosteroids for systemic use (H02), Antibacterials for systemic use (J01), Antivirals for systemic use (J05), Vaccines (J07), Antineoplastic agents (L01), Endocrine therapy (L02), Immunostimulants (L03), Immunosuppressants (L04), Anti-inflammatory and antirheumatic products (M01), Muscle relaxants (M03), Antigout preparations (M04), Drugs for treatment of bone diseases (M05), Anesthetics (N01), Analgesics (N02), Antiepileptics (N03), Anti-Parkinson drugs (N04), Psycholeptics (N05), Psychoanaleptics (N06), Other nervous system drugs (N07), Antiprotozoals (P01), Ectoparasiticides, incl. scabicides, insecticides and repellents (P03), Nasal preparations (R01), Drugs for obstructive airway diseases (R03), Antihistamines for systemic use (R06), Ophthalmologicals (S01), Otologicals (S02), Ophthalmological and otological preparations (S03), All other therapeutic products (V03), Diagnostic agents (V04), and Diagnostic radiopharmaceuticals (V09)