Table 13.

Effect of Bisphosphonate Treatment on Bone Deformity

Risk‐benefit balance

The effects of bisphosphonates on bone deformity have not been adequately studied.

Quality of evidence

Very low

Patient values and preferences

Bone deformity is of concern to patients. If treatment strategies could be identified that were effective in preventing bone deformity, it is likely that they would be favored by patients.

Costs and use of resources

Bisphosphonates are inexpensive, but intravenous therapy involves additional support costs and costs in terms of patient time attending for the infusion that may need to be considered.

Recommendation

There is insufficient evidence that bisphosphonates can prevent or treat bone deformity in PDB, and they are not recommended for this indication.