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. 2019 Feb 25;34(4):e3657. doi: 10.1002/jbmr.3657

Table 29.

Clinical Questions to Be Prioritized for Further Research in PDB

  • Risk and benefits of treating asymptomatic patients with PDB

  • Effects of treatment on complications

  • Role of genetic profiling in the diagnosis of PDB and prediction of complications

  • Clinical outcome of joint replacement surgery and osteotomy in the modern era

  • Clinical outcome after fracture fixation in the modern era

  • Effects of nonpharmacological treatments other than surgery