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. 2019 May 16;9:7468. doi: 10.1038/s41598-019-43858-4

Figure 1.

Figure 1

Mechanical allodynia of WT and CB2KO (A), CB2-LysM (B) and CB2-Syn (C) after nerve ligation. Allodynia was assessed with von Frey filaments, basal and during 14 days post SNL in ipsi- and contralateral hind paws. Ligated CB2KO and CB2-LysM mice showed increased contralateral allodynia compared to ligated WT or CB2-FL animals. Additionally, ligated CB2KO and CB2-LysM mice developed increased ipsilateral allodynia. Ligated WT and CB2-Syn mice showed a similar development of mechanical allodynia. When compared between ligated genotypes (D), mechanical allodynia of CB2KO and CB2-LysM animals was significantly increased on both sides, compared to WT animals (n = 4–8). Statistical significance was determined with a two-way ANOVA and a Bonferroni post-hoc test (A–C) or a Dunnet’s post-hoc test (D). Stars represent differences between ligated and sham animals (A–C) or between ligated CB2KO and ligated WT animals (D). *p < 0.05, **p < 0.01, ***p < 0.001. Hashtags indicate significance between CB2-LysM and WT mice. #p < 0.05, ##p < 0.01, ###p < 0.001. Error bars show SEM.