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. 2019 May 16;10:2195. doi: 10.1038/s41467-019-10182-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The STRING networks of proteins with regulated SNO sites after GSNO treatment of HeLa extracts. N = 3 biological replicates. a Proteins with significantly downregulated SNO sites, b the 500 proteins with the strongest upregulated SNO sites. Both networks indicate the role of SNO in splicing, translation, ubiquitin mediated proteolysis, DNA replication, cellular response to stress, vesicle-mediated transport, GTPase-mediated signaling and aminoacyl-tRNA biosynthesis pathways. Source data are provided as a Source Data file