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. 2019 May 16;9:7503. doi: 10.1038/s41598-019-43923-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Difference in the average event-related potentials (ERPs) between control and EGF-treated rats in the frontal cortex. ERP waveforms were recorded from an electrode on the frontal cortex in control (a)- and EGF (b)- treated rats and were grand averaged across subjects. Waveforms from the 6 kHz deviant (orange), the 3 kHz standard (sky blue), and the 6 kHz non-deviant (green) tones. The non-deviant tone has the same pitch and probability of occurrence as the deviant tone but does not stand out from the other stimuli (1, 1.5, 2, 3, 4, 5, 6, 7, 7.5 and 8 kHz). The shaded area around each ERP trace denotes the mean ± standard error (SE). The tone stimulation is marked with a thick horizontal line lasting for 100 ms. The major ERP component of N50 is marked. Data were obtained from 12 control and 12 EGF-treated rats.