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. 2019 May 16;9:7475. doi: 10.1038/s41598-019-43906-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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GA-like pathology corresponds to functional deficits in the mouse retina. Electroretinography (ERG) was used in longitudinal studies to measure the function of different retinal cell types. Average ERG traces are shown for lasered and non-lasered groups at (a) 1 week before laser, (b) 1 week after laser, (c) 2 weeks after laser, (d) 4 weeks after laser, and (e) at 8 weeks after laser. ERG values for lasered eyes were normalised to the fellow/control eye in each animal. (f) Comparison of A-wave amplitudes between lasered and non-lasered eyes. (g) Comparison of B-wave amplitudes, and (h) B-wave implicit times between lasered and non-lasered eyes. Arrows indicate point of the light stimulus. An average of 3 ERG measurements were obtained per eye at each time point (n = 8, five month old mice). Analysis by two-way ANOVA (repeated measures by both factors, factor 1: control vs. lasered eye, factor 2: time) followed with Holm-Sidak post-hoc testing. Graphs presented as mean ± SEM, significance denoted by *p < 0.05, **p < 0.01 and ***p < 0.0001.