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. 2019 May 16;10:2193. doi: 10.1038/s41467-019-10229-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A new role of protein tyrosine phosphatases (PTPs) in actin cytoskeleton regulation. a, b Airyscan confocal images of the dorsal trunk of wild-type, Ptp4EPtp10D, Btk29A⁵⁶¹⁰ and wash¹⁸⁵ embryos expressing the actin reporter btl>moeGFP (grey). Images were acquired during luminal endocytosis, 18 h after egg laying (AEL) (for wild-type, Btk29A⁵⁶¹⁰ and wash¹⁸⁵) and 17 h AEL (for Ptp4EPtp10D). Longitudinal sections (a) and Z-stack projections (b) are shown. Lower rows in a and b depict zoomed view of areas indicated by the rectangular frames. Scale bars, 10 μm. c Plots showing the relative number of actin bundles (>2 μm long) per μm (RNB) in wild type (n = 10), Ptp4EPtp10D (n = 8), Btk29A⁵⁶¹⁰ (n = 14), btl>Btk29A (type-2) (n = 11) and wash¹⁸⁵ (n = 14) embryos expressing btl>moeGFP. The boxplot shows the median (horizontal line) and the data range from 25th to 75th percentile. The bars denote maxima and minima values. *P < 0.01, **P < 0.001, ***P < 0.0001 indicates statistical significance in comparison to wild-type (unpaired two tailed t tests)