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. 2019 May 16;9:7504. doi: 10.1038/s41598-019-43668-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Correlation of CAR expression and CRAd-induced tumor inhibition in breast cancer cell lines. (a) CAR inhibition via stable transfection of CAR-siRNA diminished its protein expression in cisplatin resistant cells. (b) Ectopic CAR expression through full-length human CAR cDNA raised CAR protein levels in cisplatin sensitive cells. (c) CAR knockdown in resistant cells, MCF-7/R and M-231/R significantly reduces the CRAd-induced tumor inhibition. (d) CAR overexpression significantly increases the CRAd-induced tumor inhibition in sensitive cells, MCF-7 and M-231. The data shown in (c,d) are the average of triplicate experiments. Data are presented as the mean ± SD (n = 3), *p < 0.05 by two-tailed Student’s t test. Uncropped blots are shown in the supplementary information (See Supplementary Data, Fig. S3).