Table 4.
Output from the four generalised linear models (all of which include a fixed set of covariates plus combinations of HV metrics).
| Fixed | Model 1 (DIC = 936) | Model 2 (DIC = 1,011) | Model 3 (DIC = 924) | Model 4 (DIC = 933) | |||||
|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR | p | ||
| Intercept | 0.81 (0.06, 11.6) |
* | 0.03 (0.00, 0.29) |
** | 0.87 (0.06, 12.3) |
1.02 (0.10, 10.6) |
* | ||
| Time between Visits (year) | 2.61 (1.85, 3.67) |
*** | 2.09 (1.61, 2.72) |
*** | 2.58 (1.82, 3.65) |
*** | 2.47 (1.77, 3.43) |
*** | |
| Age at previous visit | 0.96 (0.93, 0.99) |
1.01 (0.98, 1.04) |
0.95 (0.92, 0.99) |
** | 0.95 (0.93, 0.98) |
** | |||
| Gender (ref = male) | Female | 0.85 (0.56, 1.30) |
0.95 (0.67, 1.36) |
0.83 (0.54, 1.30) |
0.84 (0.55, 1.28) |
||||
| Education (year) (ref: ≤12) | >12 | 1.09 (0.62, 1.91) |
1.09 (0.69, 1.73) |
1.08 (0.61, 1.93) |
1.10 (0.63, 1.92) |
||||
| APOE genotype (ref = −/−) | +/− | 1.75 (1.1, 2.79) |
* | 1.83 (1.26, 2.66) |
** | 1.69 (1.03, 2.77) |
* | 1.65 (1.05, 2.61) |
* |
| +/+ | 1.80 (0.91, 3.56) |
2.15 (1.25, 3.71) |
** | 1.67 (0.83, 3.35) |
1.65 (0.87, 3.13) |
||||
| Diagnosis at previous visit | MCI | 0.96 (0.56, 1.68) |
1.95 (1.25, 3.04) |
** | 0.90 (0.5, 1.61) |
0.90 (0.52, 1.56) |
|||
| HVres at previous visit (cm3) | 0.36 (0.27, 0.49) |
*** | — | 0.34 (0.25, 0.46) |
*** | 0.36 (0.26, 0.49) |
*** | ||
| HVrate since last visit (cm3/year) | — | 0.54 (0.37, 0.8) |
** | 0.53 (0.34, 0.83) |
** | 0.48 (0.24, 0.95) |
* | ||
| HVres: HVrate interaction | — | — | — | 0.92 (0.60, 1.42) |
|||||
| Random | Variance | Variance | Variance | Variance | |||||
| ID (Intercept) | 0.845 | <0.001 | 1.051 | 0.702 | |||||
Model 1: Base + HVres; Model 2: Base + HVrate; Model 3: Base + HVres + HVrate; Model 4: Base + HVres *HVrate. Abbreviations: OR = Odds ratio; CI = Confidence interval; SD = Standard deviation; DIC = Deviance Information Criterion, *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001; blank = not significant.