Table 1.
Characteristics of 28 morbidly obese patients.
| without NAFLD | with steatosis | with NASH | p | |
|---|---|---|---|---|
| n | 5 | 14 | 9 | |
| Age (years) | 39.4 ± 5.9 | 37.4 ± 2.4 | 45.8 ± 3.6 | 0.186 |
| Sex (F/M) | 4/1 | 14/0 | 4/5 | 0.005 |
| BMI (kg/m²) | 43.4 ± 0.7 | 44.1 ± 1.4 | 43.3 ± 1.8 | 0.851 |
| ALT (IU/L) | 18.20 ± 4.48 | 26.47 ± 2.95 | 81.44 ± 26.19*,# | <0.001 |
| Insulin level (mIU/L) | 7.00 ± 1.10 | 15.46 ± 3.21 | 28.67 ± 4.56*,# | 0.003 |
| Glucose level (mmol/L) | 4.88 ± 0.14 | 5.44 ± 0.13* | 6.70 ± 0.72* | 0.014 |
| HOMA-IR | 1.52 ± 0.24 | 3.77 ± 0.80* | 8.51 ± 1.36*,# | 0.001 |
| HbA1c (%) | 5.34 ± 0.22 | 5.62 ± 0.12 | 6.40 ± 0.38*,# | 0.028 |
| Triglycerides (mmol/L) | 1.05 ± 0.15 | 1.41 ± 0.17 | 3.42 ± 1.07*,# | 0.007 |
| HDL cholesterol (mmol/L) | 1.53 ± 0.18 | 1.52 ± 0.10 | 1.07 ± 0.37*,# | 0.006 |
| NAFLD Activity Score (n) | 0(5) | 1(4)/2(4)/3(6) | 5(9) | |
| Grade of steatosis (n) | 0(5) | 1(4)/2(4)/3(6) | 3(9) | |
| Lobular inflammation (n) | 0(5) | 0(14) | 1(9) | |
| Hepatocellular ballooning (n) | 0(5) | 0(14) | 1(9) |
Without NAFLD: patients with normal liver histology; Steatosis: patients with steatosis; NASH: patients with severe steatosis and NASH. Data are expressed as mean ± SEM and compared using the non parametric Kruskal-Wallis test (column p) and Mann Whitney test (*, #) for quantitative values and or Khi-deux test for qualitative values. *p < 0.05 compared with “Without NAFLD”. #p < 0.05 compared with “Steatosis”.