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. 2019 May 16;10(6):381. doi: 10.1038/s41419-019-1614-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Knockdown of PGC1α partly rescued the effect of knockdown of miR-23b in OS. a Knockdown efficacy of PGC1α in miR-23b-3p knockdown MNNG-HOS and MG63 cells were determined by western blotting. b, c PGC1α knockdown partly reversed the inhibitory effects of miR-23b-3p knockdown on the colony-formation properties of OS (MNNG-HOS and MG63) cells, values are means ± SD, **p < 0.01, ***p < 0.001. d Silencing of PGC1α partly reversed the inhibitory effects of miR-23b-3p knockdown on the CCK-8 assay of MNNG-HOS and MG63 cells, values are means ± SD, *p < 0.05, **p < 0.01. e PGC1α knockdown partly reversed the inhibitory effects of miR-23b-3p silencing on the proliferation properties of MNNG-HOS cells. Excised tumors from different groups are shown (n = 4). Scale bars = 1 cm. f PGC1α knockdown partly rescued the inhibitory effects of miR-23b-3p knockdown on the growth rate in MNNG-HOS cells in vivo. Tumor volumes were measured with calipers every 5 days, values are means ± SD, **p < 0.01. g, h Altered level of OCR and ECAR in OS cells (MNNG-HOS and MG63) in different groups (Control, knockdown-miR-23b-3p, knockdown-miR-23b-3p, and knockdown- PGC1α). Values are means ± SD. i, j. ATP level and lactate production were determined in different groups (Control, knockdown-miR-23b-3p, knockdown-miR-23b-3p, and knockdown-PGC1α). Values are means ± SD, *p < 0.05, **p < 0.01, ***p < 0.001