Fig. 7. FABP4 KO protects renal function, attenuates RIF, and reverses lipid metabolism disorders in mice.

a The serum levels of Cr, BUN, and H&E staining (400× original magnification) of the kidney tissue in FABP4 KO mice (n = 5). b Degree of fibrosis based on Masson and Sirius Red staining (400× original magnification), and Sirius Red polarized light observation (400× original magnification) in FABP4 KO mice. c The mRNA levels of α-SMA, COL1A1, COL3A1, and the protein levels of α-SMA and COL1A based on immunofluorescence staining (400× magnification) in FABP4 KO mice (n = 3). d The lipid droplets based on Oil O Red staining (400× original magnification), and the levels of TG, TC, and FFA in FABP4 KO mice. Data are presented as the mean ± SD. **p < 0.01 and *p < 0.05 Sham group compared with UUO FABP4 KO mice; ^## p < 0.01 and ^# p < 0.05 UUO WT mice group compared with UUO FABP4^−/−mice