Fig. 4. TRPV4 antagonist decreases NLRP3 inflammasome expression and proinflammatory cytokine production post-PISE.

a–c Increased hippocampal protein levels of NLRP3 (a), ASC (b) and caspase-1 (c) post-PISE were markedly attenuated by HC-067047. ^&&P < 0.01 vs. control, ^~~P < 0.01 vs. PISE, ^▲▲P < 0.01 vs. HC-067047. d–f PISE-induced increases in IL-1β (d), TNF-α (e) and IL-6 (f) protein levels were markedly blocked by HC-067047. ^&&P < 0.01 vs. control, ^~~P < 0.01 vs. PISE