Table 1.

In vitro activities of plazomicin and comparators against resistant isolates [11–16]

Species	AG	MIC50 (mg/L)	MIC90 (mg/L)	MIC range
All Enterobacteriaceae	Plazomicin	0.5	1	0.25 to 8
	AMKa	8	64	1 to > 64
	GENb	32	> 64	0.5 to > 64
	TOBc	32	> 32	0.5 to > 32
Escherichia coli	Plazomicin	0.5	1	0.5 to 4
	AMK	< 8	> 32	< 8 to 32
	GEN	8	> 8	< 2 to 8
	TOB	32	> 32	1 to 32
Enterobacter spp.	Plazomicin	0.5	1	< 0.5 to 16
	AMK	8	64	< 1 to > 64
	GEN	32	> 64	< 1 to > 64
	TOB	0.5	64	0.5 to 64
Klebsiella pneumoniae	Plazomicin	0.5	1	0.25 to 8
	AMK	32	> 32	< 8 to 32
	GEN	4	8	< 2 to 8
	TOB	32	> 32	0.5 to 64
Pseudomonas aeruginosa	Plazomicin	8	64	0.5 to > 64
	AMK	16	> 64	1 to > 64
	GEN	> 64	> 64	8 to > 64
	TOB	2	16	0.5 to > 64
Acinetobacter spp.	Plazomicin	16	32	1 to > 64
	AMK	> 64	> 64	4 to > 64
	GEN	> 64	> 64	2 to > 64
	TOB	> 64	> 64	2 to 64
Methicillin-resistant Staphylococcus aureus	Plazomicin	1	2	0.25 to 4
	AMK	16	> 64	0.5 to > 64
	GEN	32	> 64	0.25 to > 64
	TOB	–	–	–

^aAMK amikacin

^bGEN gentamicin

^cTOB tobramycin