Fig. 1.

Establishment of dual reporter transgenic rodents. (A) Schematic representation of the EGFP/ELuc dual reporter. (B) Representative images of living transgenic mouse and rats expressing GFP with cohort controls. GFP signals were excited by hand-held UV light (mouse n = 3/rats n = 3). White arrowheads show positive pups. (C) Representative images of living transgenic mouse and rats expressing both GFP and ELuc in pups with cohort controls. GFP signals were excited using an in vivo imaging system with blue excitation light (488 nm) (left). ELuc signals were detected by in vivo imaging system (right) (mouse n = 3/rats n = 3). . (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)