Figure 3. Effect of TGF-β1 on bone resorption in the proximal femoral metaphysis and endochondral growth indices of the proximal femurs.

(A) Osteoclast surfaces/bone surface (OcS/BS), (B) Number of osteoclast profiles/mm² of cancellous bone (Noc/B. Ar), (C) Number of osteoclast profiles/mm of cancellous bone (Noc/B. Pm), (D) Osteoid surface/bone surface (OS/BS), (E) Endochondral growth (EcG), (F) Growth plate width (GPW), (G) Hypertrophic cell size (HCS) and (H) Rate of chondrocyte production (RCP) in femoral epiphysis. ^*Sham + Veh vs DNV + Veh, P<0.05; ^#Sham + Veh vs Sham + TGF, P<0.05. DNV + Veh vs DNV + TGF, P<0.05; Sham + TGF vs DNV + TGF, P<0.05. For all time points per group, n=7.