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. 2019 May 14;39(5):BSR20181245. doi: 10.1042/BSR20181245

Figure 2. I-BET151 suppressed RANKL-NF-κB signal pathway in peripheral blood mononuclear cells.

Figure 2

(A) Representative images presenting the protein expression of TRAF6, BRD4, cytoplasm and nuclear p65, IκB-α, NFATc1, and OPG in response to the treatment with RANKL and M-CSF in the presence or absence of I-BET151 at indicated concentrations in peripheral blood mononuclear cells from both normal and patients with MM. β-actin was used as the loading control. The result was representative of three independent experiments. (B) The corresponding mean data were generated. Error bars represented mean ± S.D. P-values were determined by the one-way ANOVA followed by Tukey’s post hoc test; ***P<0.001, **P<0.01, *P<0.05.