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. 2019 May 14;39(5):BSR20182303. doi: 10.1042/BSR20182303

Table 1. Main effect of AQP1-KO on organs and system.

Target cell/tissue Outcome References
Red blood cell • Slightly shortened red cell life span, reduced membrane surface area, and a dramatically reduced osmotic water permeability [2]
Kidney • Inability to generate a hypertonic medullary interstitium by countercurrent multiplication [4,8–13,18,20]
• Impairment in the migration of proximal tubule cells and cell proliferation after acute kiney injury [14,15]
• Lower glomerular filtration rate (GFR) and renal blood flow [16]
Brain • Protective in a model of brain trauma [22–26]
• Reduced thermal inflammatory pain perception evoked by bradykinin, prostaglandin E2, and capsaicin as well as reduced cold pain perception and distinct electrophysiological defects [27–31]
The lungs • Changed permeability in different degree in different part [32,33]
Placenta • Lower number of embryos, lower fetal weight [37–39]
Fetal membranes • Increased amniotic fluid volume and reduced osmolality [40,41]
Peritoneum • Significantly reduced osmotically induced water movement, strongly decreased indices for AQP1-related transcellular water transport [42–44]
Eye • Reduced corneal thickness, reduces osmotic water permeability across the corneal endothelium, impaired keratocyte migration [45,46]
• Accelerated cataract formation [47,48]
Gland secretion • Reduced prohormone convertase 1/3, carboxypeptidase E, attenuated regulated secretion of ACTH, decreased dense-core secretory granule (DCSG) proteins biogenesis [49]
Cardiovascular system • Marked microcardia, decreased myocyte transverse dimensions and a significant decrease in the thickness of the arterial walls both in the aorta and mesenteric artery [54]
• Promoted atherosclerosis [55]
Digestive system • Acquired an oily appearance, manifested serum hypotriglyceridemia and developed steatorrhea with increased stool triglyceride content, and greater lipase activity [58]
Cellular level • Reduced angiogenesis, impaired cell migration, abnormal vessel formation, and abnormal microvascular anatomy [61,63,64]
• Reduced relative plasma membrane water permeability in chondrocyte [62]
HHS Vulnerability Disclosure