Table 3. Genotype frequencies of RAB5B gene SNPs loci in PCOS and controls.
| PCOS (n = 300) | Control (n = 300) | HWE P | OR (95%CI)* | P* | |
|---|---|---|---|---|---|
| rs1045435 | |||||
| GG | 255 (85.00%) | 285 (95.00%) | 0.08 | Reference | |
| GC | 32 (10.67%) | 14 (4.67%) | 2.56 (1.28–5.16) | 0.006 | |
| CC | 13 (4.33%) | 1 (0.33%) | 14.53 (1.97–299.74) | 0.001 | |
| Additive model | 1.12 (0.88–1.42) | 0.38 | |||
| Dominant model | 3.35 (1.76–6.46) | <0.001 | |||
| Recessive model | 13.54 (1.84–279.24) | 0.003 | |||
| G | 542 (90.33%) | 584 (97.33%) | Reference | ||
| C | 58 (9.67%) | 16 (2.67%) | 3.91 (2.16–7.17) | <0.001 | |
| rs11550558 | |||||
| AA | 251 (83.67%) | 286 (95.33%) | 0.06 | Reference | |
| AG | 41 (13.67%) | 13 (4.33%) | 3.59 (1.81–7.24) | <0.001 | |
| GG | 8 (2.67%) | 1 (0.33%) | 9.12 (1.15–195.71) | 0.03 | |
| Additive model | 1.14 (0.90–1.45) | 0.30 | |||
| Dominant model | 3.99 (2.08–7.77) | <0.001 | |||
| Recessive model | 8.19 (1.04–175.76) | 0.04 | |||
| A | 543 (90.50%) | 585 (97.50%) | Reference | ||
| G | 57 (9.50%) | 15 (2.50%) | 4.09 (2.22–7.64) | <0.001 | |
| rs34962186 | |||||
| TT | 261 (87.00%) | 266 (88.67%) | 0.06 | Reference | |
| TC | 34 (11.33%) | 31 (10.33%) | 1.12 (0.65–1.93) | 0.77 | |
| CC | 5 (1.67%) | 3 (1.00%) | 1.70 (0.35–9.05) | 0.71 | |
| Additive model | 1.02 (0.80–1.30) | 0.92 | |||
| Dominant model | 1.17 (0.70–1.96) | 0.62 | |||
| Recessive model | 1.68 (0.35–8.93) | 0.72 | |||
| T | 556 (92.67%) | 563 (93.83%) | Reference | ||
| C | 44 (7.33%) | 37 (6.17%) | 1.20 (0.75–1.94) | 0.49 | |
| rs705700 | |||||
| TT | 145 (48.33%) | 173 (57.67%) | 0.08 | Reference | |
| TC | 94 (31.33%) | 102 (34.00%) | 1.10 (0.76–1.60) | 0.67 | |
| CC | 61 (20.33%) | 25 (8.33%) | 2.91 (1.69–5.04) | <0.001 | |
| Additive model | 1.19 (0.90–1.58) | 0.23 | |||
| Dominant model | 1.46 (1.04–2.04) | 0.03 | |||
| Recessive model | 2.80 (1.67–4.76) | <0.001 | |||
| T | 384 (64.00%) | 448 (74.67%) | Reference | ||
| C | 216 (36.00%) | 152 (25.33%) | 1.66 (1.28–2.14) | <0.001 | |
| rs58717357 | |||||
| GG | 234 (78.00%) | 241 (80.33%) | 0.14 | Reference | |
| GC | 61 (20.33%) | 53 (17.67%) | 1.19 (0.77–1.82) | 0.48 | |
| CC | 5 (1.67%) | 6 (2.00%) | 0.86 (0.22–3.22) | 0.80 | |
| Additive model | 1.03 (0.80–1.32) | 0.86 | |||
| Dominant model | 1.15 (0.76–1.74) | 0.55 | |||
| Recessive model | 0.83 (0.22–3.11) | 0.76 | |||
| G | 529 (88.17%) | 535 (89.17%) | Reference | ||
| C | 71 (11.83%) | 65 (10.83%) | 1.11 (0.76–1.60) | 0.65 | |
| rs11171718 | |||||
| GG | 231 (77.00%) | 274 (91.33%) | 0.08 | Reference | |
| GA | 43 (14.33%) | 24 (8.00%) | 2.13 (1.22–3.73) | 0.007 | |
| AA | 26 (8.67%) | 2 (0.67%) | 15.42 (3.51–95.02) | <0.001 | |
| Additive model | 1.19 (0.93–1.52) | 0.18 | |||
| Dominant model | 3.15 (1.89–5.26) | <0.001 | |||
| Recessive model | 14.14 (3.22–87.00) | <0.001 | |||
| G | 505 (84.17%) | 572 (95.33%) | Reference | ||
| A | 95 (15.83%) | 28 (4.67%) | 3.84 (2.43–6.11) | <0.001 | |
| rs60028217 | |||||
| TT | 244 (81.33%) | 251 (83.67%) | 0.07 | Reference | |
| TA | 51 (17.00%) | 44 (14.67%) | 1.19 (0.75–1.90) | 0.50 | |
| AA | 5 (1.67%) | 5 (1.67%) | 1.03 (0.26–4.15) | 0.97 | |
| Additive model | 1.03 (0.81–1.32) | 0.86 | |||
| Dominant model | 1.18 (0.76–1.83) | 0.52 | |||
| Recessive model | \ | \ | |||
| T | 539 (89.83%) | 546 (91.00%) | Reference | ||
| A | 61 (10.17%) | 54 (9.00%) | 1.14 (0.77–1.71) | 0.56 | |
| rs772920 | |||||
| CC | 185 (61.67%) | 177 (59.00%) | 0.06 | Reference | |
| CG | 91 (30.33%) | 99 (33.00%) | 0.88 (0.61–1.27) | 0.53 | |
| GG | 24 (8.00%) | 24 (8.00%) | 0.96 (0.50–1.82) | 0.89 | |
| Additive model | 0.96 (0.73–1.25) | 0.79 | |||
| Dominant model | 0.90 (0.64–1.26) | 0.56 | |||
| Recessive model | \ | \ | |||
| C | 461 (76.83%) | 453 (75.50%) | Reference | ||
| G | 139 (23.17%) | 147 (24.50%) | 0.93 (0.71–1.22) | 0.64 |
*
Adjusted for age and BMI. Abbreviations: CI, confidence interval; HWE, Hardy–Weinberg equilibrium; OR, odds ratio; PCOS, Polycystic ovary syndrome.