Table 5. Distribution of genotype frequencies of RAB5B gene SNPs in PCOS and control subjects with different BMI.
| PCOS (n = 300) | Control (n = 300) | OR (95% CI)* | P* | |
|---|---|---|---|---|
| <23.8 kg/m2 | ||||
| rs1045435 | ||||
| GG | 68 (98.55%) | 136 (96.45%) | Reference | |
| GC/CC | 1 (1.45%) | 5 (3.55%) | 0.40 (0.02–3.63) | 0.68 |
| rs11550558 | ||||
| AA | 66 (95.65%) | 134 (95.04%) | Reference | |
| AG/GG | 3 (4.35%) | 7 (4.96%) | 0.87 (0.17–3.90) | 0.84 |
| rs705700 | ||||
| TT | 32 (46.38%) | 82 (58.16%) | Reference | |
| TC/CC | 37 (53.62%) | 59 (41.84%) | 1.61 (0.87–2.99) | 0.14 |
| rs11171718 | ||||
| GG | 64 (92.75%) | 127 (90.07%) | Reference | |
| GA/AA | 5 (7.25%) | 14 (9.93%) | 0.71 (0.21–2.23) | 0.70 |
| ≥23.8 kg/m2 | ||||
| rs1045435 | ||||
| GG | 187 (80.95%) | 149 (93.71%) | Reference | |
| GC/CC | 44 (19.05%) | 10 (6.29%) | 3.51 (1.64–7.71) | 0.001 |
| rs11550558 | ||||
| AA | 185 (80.09%) | 152 (95.60%) | Reference | |
| AG/GG | 46 (19.91%) | 7 (4.40%) | 5.40 (2.26–13.51) | <0.001 |
| rs705700 | ||||
| TT | 113 (48.92%) | 91 (57.23%) | Reference | |
| TC/CC | 118 (51.08%) | 68 (42.77%) | 1.40 (0.91–2.14) | 0.13 |
| rs11171718 | ||||
| GG | 167 (72.29%) | 147 (92.45%) | Reference | |
| GA/AA | 64 (27.71%) | 12 (7.55%) | 4.70 (2.35–9.57) | <0.001 |
*
Adjusted for age. Abbreviations: CI, confidence interval; OR, odds ratio; PCOS, polycystic ovary syndrome.