Figure 3.
Metaanalysis of observational studies examining the relationship between iron deficiency (ID) and malaria risk. Study-specific estimates and their relative contribution (percentage weight and sample size) to overall estimates are shown. Definitions of ID varied by study: Nyakeriga et al 2004 [11], ferritin <12 µg/L plus transferrin saturation <10%; Jonker et al 2012 [12], ferritin <30 µg/L; Gwamaka et al 2012 [13], ferritin <30 µg/L if C-reactive protein (CRP) <8.2 mg/L or ferritin <70 µg/L if CRP >8.2 mg/L; Barffour et al 2017 [14], ferritin <12 µg/L in children aged <5 years or <15 µg/L in children aged ≥5 years; and current study, ferritin <12 µg/L or <30 µg/L if CRP >5 mg/L in children aged <5 years or <15 µg/L in children aged ≥5 years. Abbreviations: CI, confidence interval; IRR, incidence rate ratio.