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. 2019 May 15;11(5):348–366. doi: 10.4251/wjgo.v11.i5.348

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©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Biological potential pathways as explanatory mechanisms of the association between physical activity and primary and secondary prevention of colorectal cancer/potential biomarkers in secondary prevention. SPARC: Secretory protein acidic and rich in cysteine; PGC-1 α: Peroxisome proliferator-activated receptor gamma co-activator 1α; CTKN1B: Cyclin-dependent kinase inhibitor 1B; IRS1: İnsulin receptor substrate 1; CTNNB1: Catenin beta 1; PTGS2: Prostaglandin-endoperoxide synthase 2; COX-2: Cyclooxygenase-2; TNF- α: Tumor necrosıs factor alpha; iNOS: İnducible nitric oxide synthase.