Table III.
Micro-CT measurements in male rats.
| Parameters (abbreviations) | NCD | HCD | HCD+NCD | WT | ApoE−/− |
|---|---|---|---|---|---|
| Trebecular parameter | |||||
| Percent bone volume (%) (BV/TV) | 32.615±7.401 | 18.01±3.901b | 25.614±2.834a,d | 42.858±5.627 | 33.137±4.434b |
| Bone surface density (1/mm) (BS/TV) | 8.533±1.592 | 5.687±1.138b | 6.05±0.907b | 12.359±0.941 | 10.329±0.711b |
| Trabecular thickness (mm) (Tb.Th) | 0.142±0.01 | 0.131±0.008b | 0.131±0.003a | 0.125±0.006 | 0.112±0.004b |
| Trabecular number (1/mm) (Tb.N) | 2.398±0.492 | 1.45±0.373b | 1.743±0.248b | 3.461±0.334 | 2.916±0.332b |
| Connectivity density (1/mm3) (Conn.Dn) | 57.15±15.627 | 24.165±6.569b | 28.796±8.819b | 94.164±8.384 | 110.377±17.264a |
| Trabecular separation (mm) (Tb.Sp) | 0.307±0.067 | 0.542±0.116b | 0.452±0.105c | 0.210±0.028 | 0.278±0.051b |
| Trabecular pattern factor (1/mm) (Tb.Pf) | 2.66±1.841 | 7.721±2.206b | 5.94±2.038b | −0.837±2.334 | 1.754±1.772a |
| Structure model index (SMI) | 1.105±0.25 | 1.782±0.336b | 1.526±0.278b | 0.812±0.246 | 1.267±0.176b |
| Cortical parameter | |||||
| Percent bone volume (%) (BV/TV) | 92.361±0.284 | 91.618±0.277b | 91.888±0.282 | 89.193±0.255 | 88.494±0.29b |
| Bone surface density (1/mm) (BS/TV) | 6.300±0.68 | 5.871±0.077a | 5.967±0.126 | 7.218±0.086 | 6.999±0.134b |
| Cortical thickness (mm) (Ct.Th) | 0.522±0.01 | 0.487±0.06a | 0.518±0.001c | 0.501±0.007 | 0.487±0.008b |
| Cortical area (mm2) (Ct.Ar) | 32.409±2.204 | 29.136±1.759b | 31.623±2.325c | 23.074±1.3890 | 24.392±2.358 |
NCD, normal control diet; HCD, high cholesterol diet; WT, wild-type; ApoE−/−, apolipoprotein E knockout.
a
P<0.01
b
P<0.01 vs. NCD
c
P<0.05
d
P<0.01 vs. the corresponding HCD.