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. 2019 Apr 11;19(6):4743–4752. doi: 10.3892/mmr.2019.10155

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Copyright: © Song et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — IL-17A stimulates osteoclast formation by inducing autophagy. (A) The mRNA expression of autophagy-related genes was determined using real-time quantitative polymerase chain reaction with IL-17A treatment after 48 h (mean ± standard deviation). (B) The expression of LC3 protein during IL-17A-mediated osteoclastogenesis was detected using western blot analysis. (C) Densitometric analysis of LC3-II expression. (D) Assessment of autophagy activity by transmission electron microscopy. Typical observations depict autophagosomes. (E) The quantitation of the number of autophagosomes (mean ± standard deviation). *P<0.05, **P<0.01, ***P<0.001 compared to the control group. IL-17A, interleukin IL-17A; LC3, microtubule-associated protein 1 light chain 3; con, control group.