Table 1. Prediction of disease phenotype analysis of high confidence nsSNPs in TEN1 gene using PhD-SNP and MutPred prediction tools.

S. No.	Variant ID	Variants	PhD-SNP	MutPred2
			Remark	Score	Remark
1.	rs1322628164	M2V	Neutral	0.329	Benign
2.	rs892524367	P4L	Neutral	0.543	Pathogenic
3.	rs1212831970	Y9C	Disease	0.326	Benign
4.	rs1333358260	W13G	Disease	0.684	Pathogenic
5.	rs1224481693	E14D	Neutral	0.528	Pathogenic
6.	rs1175908725	V15 F	Neutral	0.584	Pathogenic
7.	rs1328038606	G18V	Disease	0.325	Benign
8.	rs964588646	G23E	Neutral	0.744	Pathogenic
9.	rs376979590	T25M	Neutral	0.171	Benign
10.	rs1262136645	L26P	Disease	0.855	Pathogenic
11.	rs1223059981	D36N	Neutral	0.301	Benign
12.	rs1250997925	R41S	Neutral	0.221	Benign
13.	rs1178755431	L44V	Neutral	0.286	Benign
14.	rs1412009927	C58Y	Disease	0.581	Pathogenic
15.	rs977512123	L61M	Neutral	0.168	Benign
16.	rs1032051988	L61W	Neutral	0.575	Pathogenic
17.	rs889310547	P64T	Neutral	0.510	Pathogenic
18.	rs951187486	G70A	Disease	0.482	Pathogenic
19.	rs1180274799	G70S	Neutral	0.545	Pathogenic
20.	rs1445270614	Y73C	Neutral	0.901	Pathogenic
21.	rs1358892195	G77R	Disease	0.880	Pathogenic
22.	rs562062613	V88G	Neutral	0.488	Benign
23.	rs1401886733	A91V	Neutral	0.831	Pathogenic
24.	rs1016457057	R92H	Disease	0.831	Pathogenic
25.	rs759839415	R92C	Disease	0.909	Pathogenic
26.	rs905216603	V93M	Neutral	0.543	Pathogenic
27.	rs1286634889	C96Y	Disease	0.922	Pathogenic
28.	rs1286634889	C96F	Neutral	0.906	Pathogenic
29.	rs368827427	V97M	Neutral	0.707	Pathogenic
30.	rs1216398771	E106D	Neutral	0.226	Benign
31.	rs1230794805	R110W	Neutral	0.130	Benign
32.	rs1158635929	E111G	Neutral	0.280	Benign
33.	rs772974788	R119G	Neutral	0.382	Benign
34.	rs772974788	R119W	Neutral	0.277	Benign