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. 2019 Apr 11;19(6):4711–4718. doi: 10.3892/mmr.2019.10153

Figure 1.

Figure 1.

Pedigree structure and sequence chromatograms of detected novel mutations. (A) The pedigree illustrating autosomal recessive inheritance. (B) The left eye of patient III:2 with accommodative esotropia and binocular hazy corneal limbus. In order to better expose the field of vision, the patient assisted in opening the eyelids by hand. (C) The novel mutation c.772_779delGGATTTGA present in III:2, III:3 and II:1. (D) The novel mutation c.242A>G present in III:2, III:3 and II:2. Mutation position and normal sequence are indicated by black arrow and red box, respectively. (E) Multiple-sequence alignment of the Keratocan gene across different species. OD, oculus dextrus; OS, oculus sinister.