Figure 4.

Ala treatment decreases fibrotic marker protein expression. (A) Protein expression levels of CTGF, COL-1 and MMP9 were assessed in LV tissue from Ala-, Hyd- and saline control-treated SHRs by western blotting with the indicated antibodies. (B-D) Quantification of relative CTGF, COL-1 and MMP9 expression levels, which were normalized to that of GAPDH; n=6 per group. Data are presented as mean ± standard error of the mean. *P<0.05. Ala, alamandine; COL-1, collagen I; CTGF, connective tissue growth factor; Hyd, hydralazine; MMP9, matrix metalloproteinase 9; ns, no significance; SHR, spontaneous hypertensive rat.