Table 3.

The CFRs for different dosage regimens of FEP, MOX and CFZ/SBT against Enterobacteriaceae isolated from BRICS

Dosage regimens	ESBL-Ec	non-ESBL-Ec	Ec	ESBL-Kp	non-ESBL-Kp	Kp	REb	Eb
CFR50%	CFR50%	CFR50%	CFR50%	CFR50%	CFR50%	CFR50%	CFR50%
FEP 1 g iv q12h	40.69	91.61	56.69	46.46	90.97	74.63	86.78	64.03
FEP 1 g iv q8h	59.82	94.3	70.32	62.53	91.75	81.71	90.68	76.44
FEP 2 g iv q12h	58.66	93.74	66.92	61.83	91.65	79.67	90.01	73.45
FEP 2 g iv q8h	76.48	94.92	80.53	77.45	92.42	85.22	96.48	84.15
MOX 1 g iv q12h	79.13	87.72	82.65	67.34	85.6	81.37	78.32	80.85
MOX 1 g iv q8h	89.94	91.8	90.55	79.96	88.98	86.61	84.91	88.36
MOX 1 g iv q6h	92.71	92.94	92.88	83.62	89.78	87.75	86.77	90.05
MOX 2 g iv q12h	91.42	92.54	91.52	81.4	89.42	87.14	83.55	89.41
MOX 2 g iv q8h	93.55	93.66	93.53	86.27	90.75	89.61	87.99	92.27
CFZ/SBT 1.5 g iv q12h	3.01	26.62	13.02	5.93	48.09	25.16	23.86	19.43
CFZ/SBT 1.5 g iv q8h	5.68	49.96	24.62	12.93	71.19	52.71	43.06	34.32
CFZ/SBT 3 g iv q12h	4.76	39.58	20.32	9.95	63.11	47.12	36.58	29.11
CFZ/SBT 3 g iv q8h	8.19	65.16	32.15	16.57	78.42	58.38	51.09	40.68
CFZ/SBT 3 g iv q6h	11.61	74.84	37.18	19.48	81.87	62.19	57.97	45.44

Abbreviations: FEP, cefepime; MOX, moxalactam; CFZ/SBT, cefperazone/sulbactam; ESBL-Ec, ESBL-producing E. coli; non-ESBL-Ec, non-ESBL-producing E. coli; Ec, E. coli; ESBL-Kp, ESBL-producing K. pneumoniae; non-ESBL-Kp, non-ESBL-producing K. pneumoniae; Kp, K. pneumoniae; Other-Eb, other Enterobacteriaceae; Eb, Enterobacteriaceae; ESBL, extended-spectrum β-lactamase; BRICS, Blood Bacterial Resistant Investigation Collaborative System; CFR, cumulative fractions of response; CFR_50%, the bactericidal effects defined as achieving 50% fT >MIC; MIC, minimum inhibitory concentration.