Figure 5.

Example of SNP-phenotype, gene-phenotype networks and gene-SNP-phenotype networks. (A) SNP-phenotype bipartite networks simply connect SNPs to phenotypes with which they have a significant association, and do not provide information regarding MPA signatures within genes. (B) Gene-phenotype networks contain connections between genes and phenotypes. An edge will be drawn between a gene and a phenotype if that gene contains a SNP associated with that phenotype. Gene-phenotype networks do not provide information as to which type of MPA signature is exhibited. (C) Gene-SNP-phenotype networks are SNP-phenotype networks with the SNPs connected to genes in which they reside. These networks are more complicated, and MPA signatures can be deduced from their structure through further analysis, however, the network is not in a form in which MPA signatures can be extracted easily using standard network topology measures such as degree.