Table 1. Characters of included studies.

Author	Year	Local	Sample size	Average age#	Type of steroids	Primary disease	Cumulative dose in Exp group	Cumulative dose in Control group	Treatment duration	Genes	NOS score
Zhao et al. [16]	2017	China	193 (78/115)	40 (18–48)	Prednisone	Various	1400 mg	2400 mg	1Y	GRG	9
Plesa et al. [17]	2017	Caucasian	304 (32/272)	NA	Prednisone Dexamethasone	ALL	50,400 mg	54,149 mg	120W	BCL2L11	9
Karol et al.[18]	2015	Multinational	2955 (400/2555)	NA	Prednisone Dexamethasone	ALL	24,275 mg	24,275 mg	1500D	GWAS	7
X Wei [19]	2015	China	75 (45/30)	39 ± 10	Prednisone	Various	4800 mg	4800 mg	6M	ApoA1;ApoB; ApoE	8
Zhang et al. [20]	2014	China	200 (94/106)	44.5 (18–82)	Prednisolone	Various	7300 mg	7300 mg	1Y	ABCB1	7
Y Xue [21]	2014	China	322 (105/217)	39 (18–48)	Prednisone	Various	1388 mg	2400 mg	1Y	ABCB1	9
Y Cui [22]	2014	China	424 (223/201)	42.27 ± 15.71	Prednisolone	Various	7300 mg	7300 mg	1Y	ApoA5	7
P Zeng [23]	2014	China	206 (108/98)	40 ± 10	Prednisone	Various	2400 mg	2400 mg	3M	ApoB	8
Zhang et al. [24]	2013	China	200 (94/106)	44.5 (18–82)	Prednisolone	Various	7300 mg	7300 mg	1Y	PAI–1	7
Wang et al.[25]	2013	China	200 (94/106)	44.5 (18–82)	Prednisolone	Various	7300 mg	7300 mg	1Y	PON-1	6
Y Li [26]	2012	China	123 (70/53)	29 (18–73)	Prednisone	Various	480 mg	480 mg	6M	ABCB1	6
W Fang [27]	2011	China	134 (63/71)	35.17 ± 11.73	Prednisone	Various	6991 mg	5014 mg	6M	ApoB; CYP1A2	8
W Fang [28]	2011	China	134 (63/71)	35.17 ± 11.73	Prednisone	Various	6991 mg	5014 mg	6M	Factor V;GR;CBP; ApoB;CYP1A2	8
J Bond [29]	2011	U.K.	110 (43/67)	NA	Dexamethasone	ALL	68,333 mg	68,333 mg	143W	PAI-1	8
W He [30]	2009	China	48 (31/17)	32 (12–59)	Prednisone	Hemoglobinopathies	480 mg	480 mg	2M	CYP3A4/ ABCB1	7
W He [31]	2009	China	48 (31/17)	18–60	Prednisone	Various	480 mg	480 mg	6M	CYP3A4	7
Kuribayashi et al. [32]	2008	Japan	157 (34/123)	35 (9–64)	Methylprednisolone Prednisolone	RT	3227 mg	3207 mg	6M	ABCB1; ApoB; CBP	9
D French [33]	2008	U.S.A.	361 (51/310)	NA (10–20)	Prednisone Dexamethasone	ALL	15,139 mg	15,139 mg	NA	ABCB1;PAI–1 et al. 11 Genes##	7
Wang et al.[34]	2008	China	53 (16/37)	35 (16–78)	Methylprednisolone	SARS	5672 mg	4187 mg	NA	TNF-a	8
Tamura et al. [35]	2007	Japan	157 (34/123)	35 (9–64)	Methylprednisolone Prednisolone	RT	3251 mg	3215 mg	6M	GR;CYP3A4; CBP;NCoA2	9
XY Yang [36]	2007	China	127 (21/106)	34 (11–67)	Methylprednisolone Prednisone	SLE	89,173 mg	89,173 mg	5Y	ABCB1	9
Hirata et al.[37]	2007	Japan	112 (20/92)	NA	Methylprednisolone Prednisone	RT	3223 mg	3223 mg	6M	ApoA	7
Hirata et al.[38]	2007	Japan	158 (34/124)	36.1 (9–64)	Methylprednisolone Prednisolone	RT	3223 mg	3223 mg	6M	ApoB	7
Ekmekci et al. [39]	2006	Turkey	57 (19/38)	34.2 ± 9.3	NA	RT	NA	NA	20.6M	Factor V, Prothrombin	7
Celik et al.[40]	2006	Turkey	50 (11/39)	41 ± 11.79	Prednisolone	RT	8835 mg	6322 mg	18M	Factor V, Prothrombin, MTHFR	8
Relling et al. [41]	2004	U.S.A.	64 (25/39)	8.6 (2.7–18.8)	Prednisone	ALL	17,028 mg	17,867 mg	1.23Y	MDR1(ABCB1) et al. 13 Genes###	8
Asano et al. [42]	2004	Japan	137 (31/106)	36 (9–63)	Methylprednisolone Prednisolone	RT	3228 mg	3174 mg	NA	PAI-1; MTHFR	8
Asano et al. [43]	2003	Japan	80 (26/54)	NA	NA	RT	NA	NA	2Y	CYP3A4; CYP2D6; CYP2C19	7
Asano et al. [44]	2003	Japan	136 (30/106)	35.5 (9–63)	Methylprednisolone Prednisolone	RT	3227 mg	3207 mg	6M	ABCB1	8
Ferrari et al. [45]	2002	Switzerland	228 (26/202)	50 ± 12	Prednisone	RT	9600 mg	9600 mg	8Y	PAI-1	8

ALL, acute lymphoblastic leukemia; GWAS, genome-wide association study; NA, not available; RT, renal transplant; SARS, severe acute respiratory syndrome.

^#Mean ± standardization; mean/median (minimum–maximum).

^##TYMS; VDR; BGLAP; ESR1; LRP5; MTHFR; PAI-1; ABCB1(MDR1); PTH; PTHR; ACP5.

^###CYP3A4; CYP3A5; TPMT; UGT1A1; TYMS; GSTT1; GSTM1; RFC; MTHFR; GRG(NR3C1); MDR1(ABCB1); VDR; GSTP1.