Table II.
GO analysis for the predicted target genes of microRNA-1 (only the top 10 pathways are presented).
| Category | Count | P-value | Target genes |
|---|---|---|---|
| A, Biological process | |||
| GO:0051301~cell division | 17 | 4.73×10−6 | CDC6, KIFC1, KIF11, CENPF, AURKA, CENPE, CHEK2, etc. |
| GO:0006281~DNA repair | 14 | 4.97×10−6 | EXO1, CLSPN, XRCC2, BLM, GEN1, CHEK1, RAD51, etc. |
| GO:0000082~G1/S transition of mitotic cell cycle | 9 | 2.96×10−5 | CCNE2, CDC6, TYMS, DBF4, ORC6, MCM2, MCM10, etc. |
| GO:0007062~sister chromatid cohesion | 9 | 3.18×10−5 | CENPN, MAD2L1, CENPA, ZWINT, CENPF, CENPE, etc. |
| GO:0006270~DNA replication initiation | 6 | 3.53×10−5 | CNE2, CDC6, GINS4, ORC6, MCM2, MCM10 |
| GO:0032508~DNA duplex unwinding | 6 | 1.70×10−4 | GINS1, GINS2, BLM, GINS4, BRIP1, RAD54B |
| GO:0007067~mitotic nuclear division | 12 | 1.97×10−4 | CENPN, CDC6, FAM64A, KIF11, TIMELESS, CENPF, etc. |
| GO:0000070~mitotic sister chromatid segregation | 5 | 2.03×10−4 | KIFC1, MAD2L1, CENPA, ZWINT, ESPL1 |
| GO:0000732~strand displacement | 5 | 2.38×10−4 | EXO1, XRCC2, BLM, BRIP1, RAD51 |
| B, Cellular component | |||
| GO:0005654~nucleoplasm | 59 | 3.45×10−6 | E2F2, CLSPN, XRCC2, DBF4, AURKA, CBX2, MCM10, etc. |
| GO:0000785~chromatin | 8 | 7.79×10−5 | CENPF, CHEK1, MCM2, ASF1B, HMGA2, ESCO2, etc. |
| GO:0000776~kinetochore | 7 | 3.54×10−4 | DYNC1I1, MAD2L1, ZWINT, CENPF, CENPE, CENPI, CENPH |
| GO:0000811~GINS complex | 3 | 3.97×10−4 | GINS1, GINS2, GINS4 |
| GO:0000775~chromosome, centromeric region | 6 | 5.09×10−4 | CENPN, MKI67, CENPA, CENPF, CENPE, HELLS |
| GO:0000777~condensed chromosome kinetochore | 7 | 5.20×10−4 | DYNC1I1, CENPN, MAD2L1, ZWINT, CENPE, CENPK, CENPH |
| GO:0031298~replication fork protection complex | 3 | 2.70×10−3 | GINS2, GINS4, MCM10 |
| GO:0000922~spindle pole | 6 | 8.77×10−3 | DYNC1I1, CENPN, MAD2L1, ZWINT, CENPE, CENPK, CENPH |
| GO:0005634~nucleus | 80 | 9.28×10−3 | KIFC1, FIGNL1, AURKA, CBX2, MCM10, ZIC1, GLDC, etc. |
| GO:0005829~cytosol | 53 | 1.12×10−2 | TFERMT1, AURKA, GTSE1, GLDC, CCNE2, PCP4, etc. |
| C, Molecular function | |||
| GO:0003682~chromatin binding | 14 | 8.89×10−4 | EXO1, CENPF, ATAD2, CBX2, VSX1, TP73, RAD51, DLX1, etc. |
| GO:0005524~ATP binding | 32 | 1.78×10−3 | KIFC1, KIF4A, XRCC2, GCLC, ATP10B, BLM, FIGNL1,etc. |
| GO:0043138~3′-5′; DNA helicase activity | 3 | 2.88×10−3 | GINS1, GINS2, GINS4 |
| GO:0003688~DNA replication origin binding | 3 | 7.30×10−3 | ORC6, MCM2, MCM10 |
| GO:0003777~microtubule motor activity | 5 | 1.55×10−2 | DYNC1I1, KIFC1, KIF4A, KIF11, CENPE |
| GO:0030276~clathrin binding | 4 | 2.43×10−2 | SYT1, SYT2, SYT13, SYT16 |
| GO:0003697~single-stranded DNA binding | 5 | 2.55×10−2 | XRCC2, BLM, NEIL3, MCM10, RAD51 |
| GO:0004520~endodeoxyribonuclease activity | 3 | 2.81×10−2 | XRCC2, GEN1, RAD51 |
| GO:0005544~calcium-dependent phospholipid binding | 4 | 3.22×10−2 | SYT1, SYT2, SYT13, SYT16 |
| GO:0008395~steroid hydroxylase activity | 3 | 3.84×10−2 | CYP2B6, CYP2S1, CYP2W1 |
GO, Gene Ontology.