Table III.
KEGG pathway of validated target genes of microRNA-1.
| KEGG Pathway | Count | P-value | Target genes |
|---|---|---|---|
| hsa04110: Cell cycle | 12 | 3.52×10−7 | CCNE2, E2F2, CDC6, MAD2L1, DBF4, etc. |
| hsa04115: p53 signaling pathway | 6 | 1.47×10−3 | CCNE2, SERPINB5, CHEK1, CHEK2, GTSE1, etc. |
| hsa03460: Fanconi anemia pathway | 5 | 4.29×10−3 | BLM, FANCD2, BRIP1, FANCA, RAD51 |
| hsa03440: Homologous recombination | 4 | 5.56×10−3 | XRCC2, BLM, RAD54B, RAD51 |
| hsa00260: Glycine, serine and threonine metabolism | 4 | 1.27×10−2 | BHMT, PHGDH, PSAT1, GLDC |
| hsa04114: Oocyte meiosis | 5 | 4.81×10−2 | CCNE2, MAD2L1, AURKA, ESPL1, CDC25C |
| hsa05206: MicroRNAs in cancer | 8 | 6.69×10−2 | CCNE2, E2F2, SERPINB5, HMGA2, CDC25C, etc. |
A total of eight pathways were available, four of which were significant (P<0.01). KEGG, Kyoto Encyclopedia of Genes and Genomes.