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. 2019 Apr 24;19(6):5251–5262. doi: 10.3892/mmr.2019.10185

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Copyright: © Jian et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 10. — Overexpression of miR-30a-5p promotes apoptosis. (A) The MTT assay indicated that an overexpression of miR-30a-5p inhibited keloid fibroblast cell growth compared with the negative control. (B) Flow cytometry results using APC staining performed to assess (C) cell apoptosis ratios at 72 h in culture following transfection of the miR-30a-5p mimic. (D) Flow cytometry results using PI staining to analyze the effect of miR-30a-5p on keloid fibroblast cell cycle. (E) The ratios demonstrated that miR-30a-5p did not affect the cell cycle progression of keloid fibroblasts. Results are presented the mean ± standard deviation of three independent experiments (n=3-4). A two-tailed Student's t-test was used to compare the groups. *P<0.05 and **P<0.01 vs. respective NC. miR, microRNA; PI, propidium iodide; APC, allophycocyanin; NC, negative control; ns, not significant.