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. 2019 Apr 24;19(6):5251–5262. doi: 10.3892/mmr.2019.10185

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Copyright: © Jian et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — TSA decreases both the expression of collagen I and BCL2 in keloid fibroblasts. (A) COL1A1 mRNA expression was determined using reverse transcription-quantitative polymerase chain reaction following treatment with 1,000 nM TSA for 72 h in culture. (B) Western blotting was performed following treatment with 1,000 nM TSA for 72 h in culture. Results represent one of three independent experiments and were normalized to the β-actin control. n=4 for control (DMSO)- and TSA-treated groups.*P<0.05 vs. Control. TSA, trichostatin A; BCL2, B-cell lymphoma 2; DMSO, dimethyl sulfoxide.