Figure 7.

Confirmation of TSA-induced downregulation of the miR-17-92 and miR-155 miRNA clusters in keloid fibroblasts. Results are presented the mean ± standard deviation of three independent experiments with triplicate wells, and were normalized to the control gene U6 small nuclear RNA. Analysis of relative gene expression data was performed using reverse transcription-quantitative polymerase chain reaction and the 2^−ΔΔCq method (n=6–8). A two-tailed Student's t-test was used to compare the groups. *P<0.05, **P<0.01 and *** P<0.001 vs. respective control. miRNA/miR, microRNA; TSA, trichostatin A.