Table III.

Downregulated microRNAs in keloid fibroblasts treated with Trichostatin A.

miRs	Mean fold change ± SD	Notable targets	Key function
miR-10b	0.22±0.1125	CADM2, PIK3CA	Proliferation, migration
miR-339-3p	0.42±0.1862	PRL-1	Proliferation
miR-125a-5p	0.42±0.1962	BAX, BMF	Apoptosis
miR-155	0.43±0.1884	SKI, TGFβ2R	TGF-β signaling
miR-196b	0.51±0.1001	COL1A1, COL3A1	ECM synthesis
miR-345	0.51±0.0151	FOXQ1, YAP1, IRF1	Metastasis, EMT
miR-15b	0.44±0.1977	RECK, ERK1	Proliferation
miR-16	0.65±0.1977	HGF, SESN1	P53 signaling
miR-140-3p	0.64±0.1564	ATP6AP2, ATP8A1	Proliferation, invasion
miR-339-5p	0.66±0.166	NACC1, MDM2	P53 signaling

miR, microRNA; TGF, transforming growth factor; ECM, extracellular matrix; EMT, epithelial-mesenchymal transition.