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. 2019 Apr 24;19(6):5406–5416. doi: 10.3892/mmr.2019.10184

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Knockdown of IGFBP7-AS1 reduces the viability and invasion of U87 and U251 glioma cells. (A) Gene set enrichment analysis of IGFBP7-AS1 in glioblastoma samples from GSE16011 and Rembrandt datasets. (B) Interference efficiency of IGFBP7-AS1 siRNA in glioma cells analyzed via reverse transcription-quantitative PCR. (C) Cell viability of glioma cell lines following transfection with siRNA or NC measured by Cell Counting kit-8 assay. (D) Migration of glioma cells following transfection with siRNA or NC measured by wound-healing assay. Scale bar, 200 µm. (E) Invasion of glioma cells following transfection with siRNA or NC detected by Transwell assay. Scale bar, 100 µm. Each bar represents the mean ± SD of three independent experiments. *P<0.05 and **P<0.01. IGFBP7-AS1, insulin-like growth factor binding protein 7-antisense 1; NC, negative control; NES, Normalized enrichment score; OD, optical density; siRNA, small interfering RNA.