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. 2019 Apr 30;19(6):5397–5405. doi: 10.3892/mmr.2019.10210

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Copyright: © Gao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — NORAD promotes cell proliferation and glycolysis. (A) The level of NORAD was decreased in A549 cells following transfection with NORAD siRNAs (si1-NORAD and si2-NORAD). (B) NORAD-knockdown inhibited A549 cell proliferation. (C) NORAD-knockdown significantly decreased LDH activity, glucose utilization, lactate production, and increased intracellular ATP level in A549 cells. (D) The expression level of NORAD was increased in H460 cells transfected with pcDNA3-NORAD (pNORAD). (E) NORAD overexpression promoted cell proliferation in H460 cells. (F) NORAD overexpression increased LDH activity, glucose utilization, lactate production, and decreased the intracellular ATP level in H460 cells. *P<0.05 vs. control group. NORAD, non-coding RNA activated by DNA damage; NC, negative control; siRNA, small interfering RNA; LDH, lactate dehydrogenase.