Table 3.
Univariable and multivariable analysis of predictors for primary and secondary endpoints
| Univariable | Multivariable* | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P‐value | HR | 95% CI | P‐value | |
| Death and heart transplantation | ||||||
| TTNtv | 1.06 | 0.40‐2.80 | 0.901 | – | – | – |
| Male sex | 1.09 | 0.48‐2.47 | 0.841 | – | – | – |
| Age | 1.00 | 0.99‐1.03 | 0.461 | – | – | – |
| NYHA class III/IV | 2.93 | 1.29‐6.68 | 0.010 | 2.94 | 1.26‐6.86 | 0.013 |
| Heart failure events | ||||||
| TTNtv | 2.88 | 1.37‐6.07 | 0.005 | 3.25 | 1.50–7.01 | 0.003 |
| Male sex | 1.17 | 0.56‐2.45 | 0.669 | – | – | – |
| Age | 1.01 | 0.99‐1.03 | 0.385 | – | – | – |
| NYHA class III/IV | 3.58 | 1.71‐7.47 | 0.001 | 3.89 | 1.83‐8.28 | <0.001 |
Abbreviations: CI, confidence interval; HR, hazard ratio; NYHA, New York Heart Association; TTNtv, titin‐truncating variants.
*
Items with P < 0.05 in univariable analysis was then included in the calculation of multivariable HR and 95% CI.