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. Author manuscript; available in PMC: 2019 May 17.
Published in final edited form as: Bioconjug Chem. 2018 Mar 20;29(4):1364–1372. doi: 10.1021/acs.bioconjchem.8b00081

Figure 2.

Figure 2.

(A) The site-selective modification of trastuzumab with PODS-FL. The structure of trastuzumab-PODS-FL depicts only one regioisomer resulting from the conjugation reaction, though several are possible. (B) Plot of the degree of labeling (DOL) of the conjugates obtained after 2 h of reaction using different numbers of equivalent of PODS-FL under various conditions (10 equivalents of TCEP, unless specified otherwise).