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. 2019 May 10;10:541. doi: 10.3389/fphys.2019.00541

FIGURE 1.

FIGURE 1

Ibuprofen treatment attenuates expression of inflammatory mediators in IUGR piglet brains. Heat maps of inflammatory profiler arrays separated into chemokines and receptors (A), cytokines and receptors (B), and interleukins and receptors (C). Heat maps demonstrate altered expression of pro- and anti-inflammatory mediators in the cortex of IUGR relative to untreated NG. Treatment with ibuprofen largely down-regulated inflammatory genes relative to untreated NG. Expression of well-characterized pro-inflammatory (D) and anti-inflammatory (E) genes relative to NG. Ibuprofen treatment in IUGR resulted in down-regulation of pro-inflammatory (F) and up-regulation of key anti-inflammatory genes (G) when compared with untreated IUGR.