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. 2019 May 10;13:149. doi: 10.3389/fncel.2019.00149

FIGURE 3.

FIGURE 3

Evocable CMAPs amplitude areas as evaluated during electrodiagnostic recordings from the thenar muscle over 16 weeks observation period. ANG-reconstructed forelimbs showed significant improvement after 12 weeks post-surgery and significantly higher amplitudes compared to the nerve guide groups. Among the artificial nerve guide groups, no significant increase could be detected after the 16-week observation period. CNG-reconstructed forelimbs, however, revealed a significantly lower amplitude area in comparison to ANGs. The continuous horizontal line displays the pre-surgically recorded healthy nerve mean value (n = 32 forelimbs). Two-way ANOVA showed an effect of the parameters 12 vs. 4 and 8, as well as 16 vs. 4 and 8 weeks post-surgery [F(3, 112) = 19.35, p < 0.0001], groups [F(3,112) = 18.54, p < 0.0001), and the interaction between both parameters [F(9,12) = 3.534, p = 0.0007]. Tukey’s multiple comparisons were applied to detect significant differences (∗∗∗p < 0.001 vs. 4 weeks post-surgery within the same group; #p < 0.05, ###p < 0.001 vs. 8 weeks post-surgery within the same group; $$p < 0.01, $$$p < 0.001 vs. ANG). Values are given as median ± range (n = 8). ANG, autologous nerve graft; CNG, chitosan nerve guide; CNG[F], chitosan-film enhanced chitosan nerve guide; corrCNG[F], corrugated chitosan-film enhanced chitosan nerve guide.