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. 2019 May 10;13:149. doi: 10.3389/fncel.2019.00149

FIGURE 4.

FIGURE 4

Representative pictures of the macroscopic appearance of the sutured grafts right before explantation (A, B, E, F) and of the explanted regenerated tissue at 16 weeks post-surgery (C, D, G, H). For treatment of 10 mm median nerve gaps either ANGs (A, C), hollow standard CNGs (B, D), CNG[F]s (E, G), or corrCNG[F]s (F, H) were inserted and sutured at the corresponding nerve end (p = proximal, d = distal). In ANG- and CNG-reconstructed forelimbs one nerve strand was formed. On the other hand, CNG[F]s and corrCNG[F]s led to two thinner nerve strands, generally divided from each other by the z-folded chitosan-film. Perforations within the chitosan-films allowed for growth of macroscopically visible, eventually blood supplied, connections between the two nerve strands (indicated by ).