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. 2019 May 10;13:149. doi: 10.3389/fncel.2019.00149

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Copyright © 2019 Dietzmeyer, Förthmann, Leonhard, Helmecke, Brandenberger, Freier and Haastert-Talini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quantification of NF200-immunopositive axonal profiles at midgraft-level at 16 weeks post-surgery. ANG reconstructions revealed the highest numbers of NF200-positive axonal profiles among all tested implants. CorrCNG[F]s showed slightly increased numbers of immunopositive axonal profiles, when compared to the other artificial nerve guides tested. Kruskal–Wallis test [H(3, N = 28) = 7.74, p = 0.0517] followed by Dunn’s multiple comparisons were applied. No significant differences were detected. Values are given as mean ± SEM. ANG, autologous nerve graft; corrCNG[F], corrugated chitosan-film enhanced chitosan nerve guide: n = 8; CNG, chitosan nerve guide: n = 5; CNG[F], chitosan-film enhanced chitosan nerve guide: n = 7.