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. 2019 Apr 3;11(4):163. doi: 10.3390/pharmaceutics11040163

Table 3.

DOE Variables (Second level).

Independent Variables Levels
−1 0 +1
Factor 1: Dacarbazine Concentration (mg/mL) 1 2 3
Factor 2: Eugenol Concentration (mg/mL) 5 7.5 10
Dependent Variables Constraints
Response 1: Size (nm) Minimum
Response 2: Eugenol:Dacarbazine Maximum
Fixed Variables Fixed Values
Lipid Concentration 13.168 mg/mL
Water: Ethanol 5
Stirring Time 60 min
Stirring Speed 1000 rpm
Cholesterol:Lipid 1:2