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. 2019 Apr 19;9(4):78. doi: 10.3390/metabo9040078

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of isoflavones against LPS-induced oxidative stress in BV-2 murine microglia. Isoflavones exhibited no cytotoxic effects in murine microglia (A). Isoflavones (20 µM and 10 µM) reduce nitric oxide production, as determined by the Griess Reagent (B). Isoflavones inhibited the production of the pro-inflammatory cytokines, TNF-α (C) and IL-6 (D), in murine microglia. All data expressed as mean ± standard error (n ≥ 3), significance was reported by analysis of variance (ANOVA) followed with Dunnett multiple comparison testing. Significance as compared with control p ≤ 0.0001 (####); as compared with LPS, p ≤ 0.03 (*), p ≤ 0.002 (**), p ≤ 0.0002 (***) and p ≤ 0.0001 (****).